(@utomatic Threading Optimisation Modelling & Evaluation)
This pipeline offers both a fully automated server to run from the sequence to a validated protein structure model (@TOME) as well as open suite of softwares for a stepwise optimisation of sequence-structure alignment, modelling and evaluation of protein structures (TOME).
This server has been successfully evaluated during last CASP5 meeting (see PROTEINS, 53, supplement 6, 2003).
Application examples : Mycobacterial Rpfs, NAD kinases, a new phosphatase, a putative RRM, ...
Server citation: Douguet D. and Labesse G (2001), Easier threading through web-based comparisons and cross-validations, Bioinformatics, 17(8), 752-3.
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