Welcome to the Bioinformatic Tool Server @TOME

(@utomatic Threading Optimisation Modelling & Evaluation)

A pipeline dedicated to predictions of protein structures and protein-ligand interactions.

This pipeline offers both a fully automated server to run from the sequence to a validated protein structure model (@TOME) as well as open suite of softwares for a stepwise optimisation of sequence-structure alignment, modelling and evaluation of protein structures (TOME).

This server has been successfully evaluated during last CASP5 meeting (see PROTEINS, 53, supplement 6, 2003).

The latest version of @TOME is available here : @TOME V2




Evaluation examples : human Hah1

Application examples : Mycobacterial Rpfs, NAD kinases, a new phosphatase, a putative RRM, ...



Server citation: Douguet D. and Labesse G (2001), Easier threading through web-based comparisons and cross-validations, Bioinformatics, 17(8), 752-3.






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